IDO in Human Gut Graft-versus-Host Disease

Gut Microbiota in Graft-versus-Host Disease

Gut microbiota inhabit the host gastrointestinal (GI) tract and play roles in many aspects of metabolic and immunologic homeostasis. Understanding about gut microbiota composition in health and disease is accumulating with the advances in gene sequencing technology. Graft-versus-host disease (GVHD) is a major complication after allogenic bone marrow transplantation (allo-BMT), a gold standard c...

Graft Versus Host Disease

Commonly referred to as GVHD, graft-versus-host disease is a man-made condition that arises when patients are transplanted with donor tissue that is not identical to their own. Transplants from other individuals are called allogeneic (‘allo’ meaning ‘other’ and ‘geneic’ referring to ‘genes’). GVHD occurs after hematopoietic stem cell or bone marrow transplantation but is most commonly experienc...

Graft versus Host Disease

Definition Graft-versus-host disease (GVHD) is the most common complication of allogeneic hematopoietic stem cell transplantation (HSCT). In HSCT, the patient’s bone marrow is destroyed with chemotherapy and/or radiation and replaced by donor hematopoietic stem cells. In allogeneic HSCT the donor is usually a close family member or occasionally someone outside the family who has been found to b...

Graft-versus-host disease or graft-versus-host-like syndrome.

Disease severity in chronic graft-versus-host disease: doctors' gut feeling versus biostatistics?

this process is changing with it. So, what are the clinical hematologists going to do with their microscopes: use them or sell them? Mars van ‘t Veer is a consultant hematologist at Addenbrooke’s University Hospital, Cambridge, UK. Torsten Haferlach works at the MLL Munich Leukemia Laboratory, Germany. Financial and other disclosures provided by the author using the ICMJE (www.icmje.org) Unifor...